宋旭 教授 博导

简介：

国家重点研发计划首席科学家、中国遗传学会常务理事、四川省遗传学会理事长。

一直致力于研究长非编码RNA（lncRNA）与蛋白质的相互作用，以及该相互作用在肿瘤发生发展中的意义。其中，2002年-2009年期间发表的一系列论文揭示了lncRNA参与肿瘤发生发展的具体机制及效应模式，是lncRNA-蛋白质互作领域的奠基性工作之一。

2019年在Cell Research发表论文报道了凝血因子VII、IX、X是人体内天然的抗超级细菌蛋白。发现凝血因子具有凝血和抗菌双重功能，更新了人们对凝血因子的传统认知，使其研究进入了新阶段。有望改变对脓毒症、脑中风等多种血栓相关疾病病因的认识，为研制抗超级细菌药物提供了新方案。

近5年，承担了科技部国家重点研发计划项目、973课题、“重大新药创制”科技重大专项、基金委重大项目子课题、基金委重大研究计划、基金委面上项目、教育部博士点基金优先发展领域项目、四川省科技创新研究团队专项计划等项目。

联系方式：

028-85410032, xusong@scu.edu.cn

简历：

1993年毕业于四川老员工物工程系获学士学位
1996年毕业于四川老员工物工程系获硕士学位
1999年毕业于中国协和医科大学获博士学位
1999年起在美国耶鲁大学分子生物物理与生物化学系作博士后研究
2002年起任美国耶鲁大学分子生物物理与生物化学系Associate Research Scientist，Research Assistant Professor
2006年起任四川老员工命科学公司教授、博导，四川省分子生物学及生物技术重点实验室主任

主要研究方向：
肿瘤相关lncRNA的作用机制；新型抗肿瘤的核酸药物。

新型抗超级细菌感染的蛋白药物。

脓毒症、脑中风、心梗等血栓相关疾病的发病机理及防治。

机体免疫防御新机制。

代表性文章：

1. Yang G, Zhang S, Wang Y, Li L, Li Y, Yuan D, Luo F, Zhao J, Song X*, Zhao Y. Aptamer blocking S-TLR4 interaction selectively inhibits SARS-CoV-2 induced inflammation. Signal Transduct Target Ther, 7(1):120. 2022. IF: 38.104

2. Zheng G, Zhao L, Yuan D, Li J, Yang G, Song D, Miao H, Shu L, Mo X, Xu X, Li L, Song X*, Zhao Y. A genetically encoded fluorescent biosensor for monitoring ATP in living cells with heterobifunctional aptamers. Biosensors and Bioelectronics, 198:113827. 2022. IF: 12.545

3. Li L, Miao H, Chang Y, Yao H, Zhao Y, Wu F, Song X*. Multidimensional crosstalk between RNA-binding proteins and noncoding RNAs in cancer Biology. Seminars in Cancer Biology, 75:84-96. 2021. IF: 17.012

4. Zheng G, Dai J, Wang H, Li L, Yuan D, Bai S, Song X*, Zhao Y. A hairpin-mediated nicking enzymatic signal amplification for nucleic acids detection. Talanta, 251. 2021. IF: 6.556

5. Chen J, Li X, Li L, Zhang T, Zhang Q, Wu F, Wang D, Hu H, Tian C, Liao D, Zhao L, Song D, Zhao Y, Wu C, Song X*. Coagulation factors VII, IX and X are antibacterial proteins against drug-resistant Gram-negative bacteria. Cell Research, 29: 711-724, 2019. IF: 46.297

6. Miao H, Wang L, Zhan H, Dai J, Chang Y, Wu F, Liu T, Liu Z, Gao C, Li L, Song X*. A long noncoding RNA distributed in both nucleus and cytoplasm operates in the PYCARD-regulated apoptosis by coordinating the epigenetic and translational regulation. PLoS Genet, 15(5): e1008144, 2019. IF: 6.020

7. Lan Y, Xiao X, He Z, Luo Y, Wu C, Li L, Song X*. Long noncoding RNA OCC-1 suppresses cell growth through destabilizing HuR protein in colorectal cancer. Nucleic Acids Research, 46(11): 5809–21, 2018. IF: 19.16

8. Chen H, Du G, Song X*, Li L. Non-coding transcripts from enhancers: new insights into enhancer activity and gene expression regulation. Genomics, Proteomics & Bioinformatics, 15: 201-207, 2017. IF: 6.409

9. Qi W, Song X*, Li L. Long non-coding RNA-guided regulation in organisms. Science China Life Sciences, 56:891–896, 2013. IF: 10.372

10. Li L, Feng T, Lian Y, Zhang G, Garen A, Song X*. Role of human noncoding RNAs in the control of tumorigenesis. Proc. Natl. Acad. Sci. U S A.,106 (31): 12956-61, 2009. IF: 12.779

11. Wang G, Cui Y, Zhang G, Garen A, Song X*. Regulation of proto-oncogene transcription, cell proliferation, and tumorigenesis in mice by PSF protein and a VL30 noncoding RNA. Proc. Natl. Acad. Sci. U S A., 106 (39): 16794-98, 2009. IF: 12.779

12. Garen A, Song X. Regulatory roles of tumor-suppressor proteins and noncoding RNA in cancer and normal cell functions. Int J Cancer. 122(8):1687-9, 2008. IF: 7.316

13. Song X, Sun Y, Garen A. From the cover: Roles of PSF protein and VL30 RNA in reversible gene regulation. Proc. Natl. Acad. Sci. U S A.,102(34): 12189-93. 2005 (Cover story). IF: 12.779

14. Song X, Sui A, Garen A. Binding of mouse VL30 retrotransposon RNA to PSF protein induces genes repressed by PSF: Effects on steroidogenesis and oncogenesis. Proc. Natl. Acad. Sci. U S A. 101(2): 621-6, 2004. IF: 12.779

15. Song X, Wang B, Bromberg M, Hu Z, Konigsberg W, Garen A. Retroviral-mediated transmission of a mouse VL30 RNA to human melanoma cells promotes metastasis in an immunodeficient mouse model. Proc. Natl. Acad. Sci. USA. 99: 6269-6273. 2002. IF: 12.779

16. Song X, Bao M, Li D, Li Y. Advanced glycation in D-galactose induced mouse aging model. Mech Ageing Dev, 108: 241-253, 1999. IF: 5.498