李静，博士，教授，博士生导师

• 国际自然保护联盟IUCN灵长类专家组成员

• 中国动物学会灵长类分会常务理事

• 中国动物学会动物生态专委会委员

• 中国动物学会生物进化理论专委会理事

• 四川省实验动物学会副理事长

• 四川省实验动物学会非人灵长类专委会主任

• 四川老员工物资源与生态环境教育部重点实验室副主任

联系方式：Email: ljtjf@126.com

办公室：四川老员工命公司B504室

学习工作简历

1989年9月--1993年7月，华中农业大学水产公司，获学士学位；

1993年9月--1996年7月，华中农业大学攻读免疫学硕士研究生，获理学硕士学位；

1996年7月至今，四川老员工命科学公司，讲师、副教授，教授

2001年9月—2004年7月，四川老员工命科学公司攻读博士，获理学博士学位。

2008年2月—2009年2月，美国路易斯安那州立大学，博士后

2015年8月-2015年9月，英国牛津大学圣埃德蒙公司，访问学者

招生学科：0710生物学：动物学、生物信息学

0713生态学：保护生物学

研究方向

以西南地区珍稀濒危动物为对象，结合基因组学、生物信息学及实验室技术开展保护遗传学研究。主要方向包括：1）猕猴动物的系统发育、基因渐渗、遗传多样性及种群遗传学；2）大熊猫微卫星、逆转座子等遗传标记的筛选及其应用；3）珍稀濒危动物DNA条形码研究等。

科研项目

1. 国家自然科学基金面上项目，基于泛基因组揭示普通猕猴种内遗传变异及其适应性演化机制，2024/1-2027/12，主持

2. 国家自然科学基金面上项目，普通猕猴全基因组拷贝数变异及其对猕猴适应性表型的影响研究，2022/1-2025/12，主持

3. 四川省科技厅应用基础项目，联合多组学技术研究自发糖尿病猕猴的遗传机理，2021/1-2022/12，主持

4. 大熊猫中心开放课题，基于代谢组学的大熊猫不同年龄及繁殖季节代谢研究，2020/1-2022/12，主持

5. 四川省科技厅省院省校合作项目，非人灵长类两种复杂疾病动物模型的筛选，2020/1-2022/12，主持

6. 国家自然科学基金面上项目，基于从头组装的参考基因组和种群重测序研究红面猴进化历史及近缘物种的渐渗杂交机制（NO 31770415），2018/1-2021/12，主持

7. 国家自然科学基金重点项目子课题，猕猴属物种系统发育与适应进化研究（NO 31530068），2016/1-2020/12，主持

8. 大熊猫繁育基金项目，基于全基因组的川金丝猴遗传标记开发及其在圈养种群遗传管理中的应用，2018/1-2020/12, 主持

9. 四川省应用基础研究，藏酋猴微卫星和SNP分子标记的筛选及其在圈养种群遗传管理中的应用，2015/1-2018/12, 主持

10. 大熊猫繁育基金项目，大熊猫Can-SINEs逆转座子基因组多样性研究，2015/1-2017/12, 主持

11. 自然科学基金项目，Alu逆转座子及其在猕猴属动物系统进化和种群遗传学中的运用研究，2013/1-2016/12，主持

12. kaiyun开云官方网站优秀青年基金，Can-SINEs逆转座子在大熊猫系统进化中的应用，2013/1- 2015/12，主持

13. 国家留学回国人员启动基金，藏酋猴逆转座子Alu的筛选及其在种群遗传学中的应用（20111568-8-3），2012/1-2014/12, 主持

14. 四川省杰出青年学术带头人计划，基于逆转座子Alu的猕猴属的系统进化及物种鉴别研究（2011JQ0022），2011/1-2013/12，主持

15. 自然科学基金项目，麻疯树种子杀虫活性成分及其作用机制的研究，2009年1月-2011年12月，主持

16. 四川省应用基础研究，四川省珍稀濒危动物DNA条形码研究，2009/1-2010/12，主持

17. 自然科学基金项目，麻疯树种子杀虫活性成分及其作用机制的研究，2009年1月-2011年12月，主持

18. 四川省应用基础研究，四川省珍稀濒危动物DNA条形码研究，2009/1-2010/12，主持

科技成果

1. 四川省科技进步二等奖，2015，登记号：9512015Y1603，濒危动物线粒体基因组及物种分子鉴定技术研究与应用，排名第二。

2. 湖北省科学技术进步二等奖，1998年，“草鱼细菌性烂鳃和肠炎二联菌苗的研究”，排名第四。

3. 发明专利：从麻疯树种子中提取杀虫活性成分及麻疯树萜醇I的方法和应用 （专利号：zl 200610020278.0）

4. 发明专利：麻疯树佛波酯杀虫水乳剂及其制备方法（专利号：zl 2012100377865.0）

5. 发明专利：一种唾液乳杆菌及其应用（申请号：202211242871 .5）

研究论文

Chunhui Zhang, Lei Wang, Liang Dou, Bisong Yue, Jinchuan Xing^* and Jing Li^,* Transposable Elements Shape the Genome Diversity and the Evolution of Noctuidae Species. Genes, 2023, 14(6), 1244

Fangyuan Liu, Rengui Li, Yi Zhong, Xu Liu, Wenwen Deng, Xiaoyu Huang, Megan Price, Jing Li*，Age-related alterations in metabolome and microbiome provide insights in dietary transition in giant pandas. mSystems, 2023. 8(3):e0025223.

Shengzhi Yang, Zhenxin Fan, Jiawei Li, Xinqi Wang, Yue Lan, Bisong Yue, Miao He, Anyun Zhang & Jing Li*. Assembly of novel microbial genomes from gut metagenomes of rhesus macaque, Gut Microbes, 2023, 15:1, 2188848.

Yuchen Xie, Siwei Liang, Yifan Zhang, Taoqing Wu, Yongmei Shen, Shun Yao and Jing Li*. Discovery of indole analogues from Periplaneta americana extract and their activities on cell proliferation and recovery of ulcerative colitis in mice. Frontiers in Pharmacology, 2023, 14:1282545

Yidong Guo, Kanghua Liu, Xiting Yang, Zheng Lv, Kelei Zhao, Xinrong Wang, Yiwen Chu, Jing Li*, Ting Huang*. Multi‑omics‑based characterization of the influences of Mycobacterium tuberculosis virulence factors EsxB and PPE68 on host cells. Archives of Microbiology. 2023，205:230.

Hua Liu, Jinxia Luo, Wei Hou, Xuan Pan, Yansen Cai, Jing Li*. An Effective Microsatellite Marker Panel for Noninvasive Samples in Tibetan Macaques. International Journal of Primatology, 2023,44:399-415.

Siwei Liang, Yifan Zhang, Jing Li,* and Shun Yao,* Phytochemical Profiling, Isolation, and Pharmacological applications of Bioactive Compounds from Insects of the Family Blattidae Together with Related Drug Development. Molecules, 2022, 27, 8882.

Hong Qiu, Haobo Li, Ruiwen Fan, Yang Song, Xuan Pan, Chunhui Zhang and Jing Li*. Genome- Wide DNA Methylation Profile Indicates Potential Epigenetic Regulation of Aging in the Rhesus Macaque Thymus. International Journal of Molecular Science. 2022, 23, 14984.

Cong Jiang, Xuan Pan, Jinxia Luo, Xu Liu, Lin Zhang, Yun Liu, Guanglun Lei, Gang Hu and Jing Li*. Alterations in microbiota and metabolites related to spontaneous diabetes and pre-diabetes in rhesus macaques. Genes 2022, 13, 1513.

Shengzhi Yang, Yu Liu, Nan Yang, Yue Lan, Weiqi Lan, Jinyi Feng, Bisong Yue, Miao He, Liang Zhang, Guanglun Lei, Anyun Zhang, Megan Price, Jing Li*, Zhenxin Fan*. The gut microbiome and antibiotic resistome of chronic diarrhea rhesus macaques and its similarity to the human gut microbiome. Microbiome. 2022, 10:29.

Rusong Zhang, Chuang Zhou, Xianlin Jin, Kanghua Liu, Zhenxin Fan, Jinchuan Xing, Jing Li*. Chromosome-level genome assembly of Tibetan macaque and species specific structural variations. Zoological Research, 2022, 43(5), 880-885.

Xuan Pan, Fangyuan Liu, Yang Song, Hongrun Wang, Lingyun Wang, Hong Qiu, Megan Price and Jing Li*. Motor stereotypic behavior was associated with immune response in macaques: insight from transcriptome and gut microbiota analysis. Frontiers in Microbiology. 2021，12:644540

Yang Song, Cong Jiang, Kun-Hua Li, Jing Li, Hong Qiu, Megan Price, Zhen-Xin Fan, Jing Li*. Genome-wide analysis reveals signatures of complex introgressive gene flow in macaques (genus Macaca). Zoological Research, 2021, 42(4): 433-449.  

Hua Liu, Wei Hou, Li Peng, Changjun Peng, Yansen Cai and Jing Li.* Novel SNP Markers for Non-invasive Samples in Tibetan Macaque (Macaca thibetana). Pakistan J. Zool., 2020, 52.

Lan Jiang, Qiao Yang, Jianqiu Yu, Xuanzhen Liu, Yansen Cai, Lili Niu, Jing Li*. Identification and expression analysis of lncRNA in seven organs of Rhinopithecus roxellana. Functional & Integrative Genomics, 2021, 21:543-555.

Jing Li, Zhenxin Fan, Feichen Shen, Amanda L Pendleton, Yang Song, Jinchuan Xing, Bisong Yue, Jeffrey M Kidd, Jing Li*. Genomic copy number variation study of nine Macaca species provides new insights into their genetic divergence, adaptation and biomedical application. Genome Biology and Evolution, 2020, 12：2211–2230.

Qiao Yang, Jianqiu Yu, Lan Jiang, Xuanzhen Liu, Fangyuan Liu, Yansen Cai, Lili Niu, Megan Price, Jing Li,* Identifcation and expression profle of microRNA in seven tissues of the Golden snub‑nosed monkey. Mol Genet Genomics. 2020, 295:1547–1558

Lianming Du, Tao Guo, Qin Liu, Jing Li, Xiuyue Zhang, Jinchuan Xing, Bisong Yue, Jing Li,* and Zhenxin Fan*. MACSNVdb: a high-quality SNV database for interspecies genetic divergence investigation among macaques. Database, 2020, 1–8.

YanSen Cai, HaoYangYu, Hua Liu, Cong Jiang, Ling Sun, LiLi Niu, XuanZhen Liu, DaYong Li & Jing Li*. Genome‑wide screening of microsatellites in golden snub‑nosed monkey, for the development of a standardized genetic marker system. Scientific Reports. 2020, 10:10614.

Shi Qiu, Hua Liu, Zuoyi Jian, Zhenxin Fan, Sanxu Liu, Jinchuan Xing, Jing Li*. Characterization of the primate TRIM gene family reveals the recent evolution in primates. Molecular Genetics and Genomics. 2020, 295:1281–1294.

Shi Qiu, Hua Liu, Yan-Sen Cai, Wei Hou, Liang Dou, Xiu-Yue Zhang and Jing Li*. Complete mitochondrial genome and the phylogenetic position of the common cuckoo, Cuculus canorus bakeri. Mitchondrial DNA Part B. 2019, 4(2):2802–2803.

Weideng Wei , Gai Luo, Jianghong Ran, Jing Li*. Zilong: A tool to identify empty images in camera-trap data. Ecological Informatics. 2020, 55: 101021

Changjun Peng, Lili Niu, Jiabo Deng, Jianqiu Yu, Xueyan Zhang, Chuang Zhou, Jinchuan Xing and Jing Li^*. Can-SINE dynamics in the giant panda and three other Caniformia genomes. Mobile DNA, (2018) 9:32-46.

Jing Li , Zhenxin Fan, Tianlin Sun, Changjun Peng, Bisong Yue and Jing Li^*. Comparative Genome-Wide Survey of Single Nucleotide Variation Uncovers the Genetic Diversity and Potential Biomedical Applications among Six Macaca Species. International Journal of Molecular Sciences. 2018, 19, 3123-3147.

Fan, Z., Zhou, A., Osada, N., Yu, J., Jiang, J., Li, P., Du, L., Niu, L., Deng, J., Xu, H., Xing, J., Yue, Bisong^*, Jing Li^*, Ancient hybridization and admixture in macaques (genus Macaca) inferred from whole genome sequences, Molecular Phylogenetics and Evolution. 2018, 127:376-386

San-Xu Liu, Wei Hou, Xue-Yan Zhang, Chang-Jun Peng, Bi-Song Yue, Zhen-Xin Fan, Jing Li^*, Identification and characterization of short tandem repeats in the Tibetan macaque genome based on resequencing data. 2018, Zoological Research, 39(4): 291–300.

Juan-Juan Zhu, Shun Yao, Xin Guo, BiSong Yue, XiuYing Ma and Jing Li^*. Bioactivity-guided screening of wound-healing active constituents from American cockroach. Molecules, 2018, 23, 101

Peng Li, Lianming Du, Wujiao Li, Zhenxin Fan, Daiwen Zeng, Hui Chen, Liang Zhou, Yong Yi, Na Yang, Kefeng Dou, Bisong Yue and Jing Li*. Generation and characterization of the blood transcriptome of Macaca thibetana and comparative analysis with M. mulatta. Mol. BioSyst., 2017, 13, 1121-1130.

Sanxu Liu，Wei Hou, Tianlin Sun, Yongtao Xu, Peng Li, Bisong Yue, Zhenxin Fan, Jing Li^*. Genome-wide mining and comparative analysis of microsatellites in three macaque species. Mol Genet Genomics., 2017, 292:537–550.

Jing Li, Yaoyao Cui, Juan Jiang, Jianqiu Yu, Lili Niu, Jiabo Deng, Fujun Shen, Liang Zhang, Bisong Yue, Jing Li^*. Applying DNA barcoding to conservation practice: a case study of endangered birds and large mammals in China. Biodiversity and Conservation, 2017, 26(3): 653-668.

Wenhua Qi, Chaochao Yan, Wujiao Li, Xuemei Jiang, Guangzhou Li, Xiuyue Zhang, Tingzhang Hu, Jing Li^*, Bisong Yue. Distinct patterns of simple sequence repeats and GC distribution in intragenic and intergenic regions of primate genomes. Aging-US, 2016, 8:1-20.

Juan Jiang, Jianqiu Yu, Jing Li, Peng Li, Zhenxin Fan, Lili Niu, Jiabo Deng, Bisong Yue, Jing Li^*. Mitochondrial genome and nuclear markers provide new insight into the evolutionary history of macaques. PLoS One 2016, 11(5): e0154665.

Wei Hou, Sanxu Liu, Juan Jiang, Zhenxing Fan, Pengfei Fan, Jing Li^*. The complete mitochondrial genome of White-cheeked macaque. Mitochondrial DNA Part B: Resources, 2016, 1:1, 374-375.

Yaoyao Cui, Chaochao Yan, Tianlin Sun, Jing Li, Bisong Yue, Xiuyue Zhang, Jing Li^*. Identification of CR1 retroposons in Arborophila rufipectus and their application to Phasianidae phylogeny. Molecular Ecology Resources, 2016, 16: 1037–1049. C

Zongtao Liu，Yaoyao Cui,Jianqiu Yu, Lili Niu, Jiabo Deng, Juan Jiang, and Jing Li^*，The complete mitochondrial genome of Stump-tailed Macaques (Macaca arctoides)，Mitochondrial DNA, 2016，27(3): 1742-1743.

Juan Jiang, Peng Li, Jianqiu Yu, Guang Zhao, Yong Yi, Bisong Yue, and Jing Li^*，The complete mitochondrial genome of Assamese Macaques (Macaca assamensis), Mitochondrial DNA, 2016, 27(1): 226-227.

Huawei Guo, Juan Jiang, Yaoyao Cui, Yong Yi, Xiaodong Jia, Hongxing Wang, Bisong Yue, Jing Li. Identif ication and characterization of polymorphic Alu insertions in the Tibetan macaque. Eur J Wildl Res.，2015，61:143–149

Jing Li, Xin Zheng, Yansen Cai, Xiuyue Zhang, Min Yang, Bisong Yue, Jing Li^*，DNA barcoding of Murinae (Rodentia: Muridae) and Arvicolinae (Rodentia: Cricetidae) distributed in China. Molecular Ecology Resources, 2015, 15:153-167.

Zhenxin Fan, Guang Zhao, Peng Li, Naoki Osada, Jinchuan Xing, Yong Yi, Lianming Du, Pedro Silva, Hongxing Wang, Ryuichi Sakate, Xiuyue Zhang, Huailiang Xu, Bisong Yue^*, Jing Li^*，Whole genome sequencing of Tibetan macaque provides new insight into the macaque evolutionary history，Molecular Biology and Evolution，2014,31 (6):1475-1489.